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New vaccine kills HIV in monkeys. And it comes to people after 5 years

The world sees momentum in the effort to find a cure for HIV.

A team of researchers in Japan has developed a vaccine that has been able to kill a type of human immunodeficiency virus (HIV) in macaques during an early trial, which raises hope among more than 37.7 million people living with HIV to end the AIDS pandemic, Asahi Shimbun, reports a Japanese newspaper.

And it can start testing on humans in just five years.

AIDS vaccine

Fortunately, AIDS is no longer a fatal disease as long as the patient continues to be treated with medication; however, current drugs do not kill the virus. Instead, people with HIV take a combination of HIV medications to reduce the amount of virus in their bodies, and this can reduce the amount of virus in the body to undetectable levels. While reducing the amount of virus in the body to undetectable levels means the virus can no longer be transmitted, the most effective antiretroviral therapy drugs are not yet able to completely eliminate the virus. And long-term use of such treatments is not only expensive, but can also lead to side effects and the development of a drug-resistant virus.

However, this may begin to change. The researchers created a vaccine using a specific bacterium that boosts the immune response, and then paired it with an AIDS-causing virus that had been weakened.

Seven test subjects of crab-eating macaques became infected with monkey HIV, but the tests failed to detect the virus, according to a study published in National Medical Library. Even after being injected with a more powerful virus that could have been deadly, the virus disappeared without a trace in six of the seven subjects tested.

Researchers are now trying to create a vaccine for people using HIV from patients receiving drug therapy.
And this is not the only remarkable effort to create an HIV vaccine. Moderna, a pharmaceutical company based in the United States, recently began trials on humans for their mRNA-based HIV vaccine, which uses the same technology as the widely used COVID-19 vaccine. These studies consisted of 56 adults between the ages of 18 and 50 who did not have HIV and tested for safety, immune responses and antibodies. While some say that mRNA technology is changing the game may not work as well with HIV as it mutates much faster and avoids the body’s immune system, time will tell whether the experiment will be successful or not.





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